As the perfect companion to introduction to ethics courses, Dell'Olio and Simon's reader includes the most influential ethical theories without overwhelming the beginning student. It contains a variety of readings encompassing contemporary and classic philosophers, male and female perspectives of both western and non-western ethical traditions, and readings in both theoretical and applied ethics as well as a section on 'living the good life.' Useful introduction with thought provoking study questions and suggestions for further readings accompany each chapter which (...) make it easier for students to understand and appreciate their reading. (shrink)

We suggest that the sensorimotor “theory” of vision is really an unstructured collection of separate ideas, and that much of the evidence cited in its favor at best supports only a subset of these ideas. As an example, we note that work on change blindness does not “vindicate” (or even speak to) much of the sensorimotor framework. Moreover, the ideas themselves are not always internally consistent. Finally, the proposed framework draws on ideas initially espoused by James Gibson, but does little (...) to differentiate itself from those earlier views. For even part of this framework to become testable, it must specify which sources of evidence can support or contradict each of the component hypotheses. (shrink)

Institutional review boards are almost universally considered to be overworked and understaffed. They also require substantial commitments of time and resources from their members. Although some surveys report average IRB memberships of 15 people or more, federal regulations require only five. We present data on IRB meetings at eight of the top 25 academic medical centers in the United States funded by the National Institutes of Health. These data indicate substantial contributions from primary reviewers and chairs during protocol discussions but (...) little from other members, which implies that it may be possible for smaller IRBs to accomplish the same tasks with no reduction in the quality of review. (shrink)

Protein–protein interactions are thought to be mediated by domains, which are autonomous folding units of proteins. Recently, a second type of interaction has been suggested, mediated by short segments termed linear motifs, which are related to recognition elements of intrinsically disordered regions. Here, we propose a third kind of protein–protein recognition mechanism, mediated by disordered regions longer than 20–30 residues. Bioinformatics predictions and well‐characterized examples, such as the kinase‐inhibitory domain of Cdk inhibitors and the Wiskott–Aldrich syndrome protein (WASP)‐homology domain 2 (...) of actin‐binding proteins, show that these disordered regions conform to the definition of domains rather than motifs, i.e., they represent functional, evolutionary, and structural units. Their functions are distinct from those of short motifs and ordered domains, and establish a third kind of interaction principle. With these points, we argue that these long disordered regions should be recognized as a distinct class of biologically functional protein domains. (shrink)

Protein–protein interactions are thought to be mediated by domains, which are autonomous folding units of proteins. Recently, a second type of interaction has been suggested, mediated by short segments termed linear motifs, which are related to recognition elements of intrinsically disordered regions. Here, we propose a third kind of protein–protein recognition mechanism, mediated by disordered regions longer than 20–30 residues. Bioinformatics predictions and well‐characterized examples, such as the kinase‐inhibitory domain of Cdk inhibitors and the Wiskott–Aldrich syndrome protein (WASP)‐homology domain 2 (...) of actin‐binding proteins, show that these disordered regions conform to the definition of domains rather than motifs, i.e., they represent functional, evolutionary, and structural units. Their functions are distinct from those of short motifs and ordered domains, and establish a third kind of interaction principle. With these points, we argue that these long disordered regions should be recognized as a distinct class of biologically functional protein domains. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

People often fail to detect large changes to scenes, provided that the changes occur during a visual disruption. This phenomenon, known as ''change blindness,'' occurs both in the laboratory and in real-world situations in which changes occur unexpectedly. The pervasiveness of the inability to detect changes is consistent with the theoretical notion that we internally represent relatively little information from our visual world from one glance at a scene to the next. However, evidence for change blindness does not necessarily imply (...) the absence of such a representation-people could also miss changes if they fail to compare an existing representation of the pre-change scene to the post-change scene. In three experiments, we show that people often do have a representation of some aspects of the pre-change scene even when they fail to report the change. And, in fact, they appear to ''discover'' this memory and can explicitly report details of a changed object in response to probing questions. The results of these real-world change detection studies are discussed in the context of broader claims about change blindness. (shrink)

In this paper, we develop the notion of a natural convention, and illustrate its usefulness in a detailed examination of indirect requests in English. Our treatment of convention is grounded in Lewis’s seminal account; we do not here redefine convention, but rather explore the space of possibilities within Lewis’s definition, highlighting certain types of variation that Lewis de-emphasized. Applied to the case of indirect requests, which we view through a Searlean lens, the notion of natural convention allows us to give (...) a nuanced answer to the question: Are indirect requests conventional? In conclusion, we reflect on the consequences of our view for the understanding of the semantics/pragmatics divide. (shrink)

forall x: Dortmund is an adaptation and German translation of forall x: Calgary. As such, it is a full-featured textbook on formal logic. It covers key notions of logic such as consequence and validity, the syntax of truth-functional (propositional) logic and truth-table semantics, the syntax of first-order (predicate) logic with identity and first-order interpretations, formalizing German in TFL and FOL, and Fitch-style natural deduction proof systems for both TFL and FOL. It also deals with some advanced topics such as the (...) syntax and (Kripke-)semantics of modal logic. The book is provided in PDF and in LaTeX source code. A booklet with solutions for the exercises in the book is available. (shrink)

We study the handicap principle in terms of the Sir Philip Sidney game. The handicap principle asserts that cost is required to allow for honest signalling in the face of conflicts of interest. We show that the significance of the handicap principle can be challenged from two new directions. Firstly, both the costly signalling equilibrium and certain states of no communication are stable under the replicator dynamics ; however, the latter states are more likely in cases where honest signalling should (...) apply. Secondly, we prove the existence and stability of polymorphisms where players mix between being honest and being deceptive and where signalling costs can be very low. Neither the polymorphisms nor the states of no communication are evolutionarily stable, but they turn out to be more important for standard evolutionary dynamics than the costly signalling equilibrium. (shrink)

Taking as its point of departure Leder's phenomenological discussion of the `absent' body, this article explores the nature of human corporeality as a site of transgression. The body, I argue, using a process metaphysic, is first and foremost excessive, driven by human desire rather than animal need: a sensual mode of existence organized around the pleasure/pain axis. To be excessive/transgressive, however, implies the crossing of boundaries or limits which vary according to history and culture, time and place. These issues are (...) illustrated through a range of thinkers from Bakhtin to Kristeva, Irigaray to Deleuze and Guattari. A full-scale endorsement of the poststructuralist position is, however, rejected in favour of an approach which steers a middle ground between these transgressive, more fluid arguments and a foundationalist ontology of the emotional body as an ongoing structure of lived experience. The article concludes with some reflections on the complex pattern of corporeal `appearances', some more pleasant than others, which characterize our bodily-being-in-the-world. (shrink)

Traditional mechanistic accounts of language processing derive almost entirely from the study of monologue. Yet, the most natural and basic form of language use is dialogue. As a result, these accounts may only offer limited theories of the mechanisms that underlie language processing in general. We propose a mechanistic account of dialogue, the interactive alignment account, and use it to derive a number of predictions about basic language processes. The account assumes that, in dialogue, the linguistic representations employed by the (...) interlocutors become aligned at many levels, as a result of a largely automatic process. This process greatly simplifies production and comprehension in dialogue. After considering the evidence for the interactive alignment model, we concentrate on three aspects of processing that follow from it. It makes use of a simple interactive inference mechanism, enables the development of local dialogue routines that greatly simplify language processing, and explains the origins of self-monitoring in production. We consider the need for a grammatical framework that is designed to deal with language in dialogue rather than monologue, and discuss a range of implications of the account. Key Words: common ground; dialogue; dialogue routines; language comprehension; language production; monitoring; perception-behavior link. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Save Us From Being Saved:Girard's Critical SoteriologySimon J. Taylor (bio)One of the most striking things about the work of René Girard is that it is an overarching critique of what it is to be saved. The paradox that Girard presents us with is that "salvation" is something from which we must be saved. This combination of salvation as something that must be avoided and something we desperately need appears (...) to have the characteristic of a "double bind," about which Girard has written so much.1 Are we then, even within Girard's own thesis, bound to the mimetic doubling of need and revulsion that can end only in the expulsion or death of a common victim? It is this question that I hope to explore in this article.Girard's Critique Of SalvationTo set out Girard's critique of salvation, it is first necessary to see that what he has come to call the victimage mechanism ("mécanisme victimaire") is, in fact, salvation. Girard's thesis states that desire is mimetic, based on the imitation of another's desire. "Desire is always an imitation of another desire, desire for the same object, and therefore, an inexhaustible source of conflicts and rivalries" (Girard 1978, 39). As the rivalry produced by this desire intensifies, it spreads and produces conflict and violence on a large scale. On an unlimited scale, Girard identifies this with the Hobbesian "war of all against all."2 And it is at this point that the victimage mechanism kicks in. It is at this point that the identification of a scapegoat and the expulsion or killing of the scapegoat produce unity and restore peace. It is this, in Girard's originary scene, that leads to the simultaneous origins of society and religion. In restoring unity to the group, and hence founding the community, the victim becomes sacred, a god. This in itself is an indicator of the salvific power that the scapegoat effects in the community. In order that the violence, once diverted, should not break out again, two things are necessary: ritual, specifically sacrifice, and myth. Ritual reenacts the founding murder upon which society is based, enabling the [End Page 21] participants to transfer their violence to another victim. Myth is the story told by the persecutors about the events that led to the creation of their community, that is, the founding murder. Thus, religion "dehumanizes violence; it protects man from his own violence by taking it out of his hands, transforming it into a transcendent and ever-present danger to be kept in check by the appropriate rites appropriately observed and by a modest and prudent demeanor.... religion protects man as long as its ultimate foundations are not revealed" (Girard 1978, 134–35). Salvation has happened, and a cult arises to disburse the effects of this salvation.It is important that we take this account of religion with full seriousness and do not regard it simply as the prologue to Girard's later promotion, even rehabilitation, of the Judaeo-Christian tradition. This is salvific: religion protects us from our own violence; it has mechanisms for bringing to an end outbreaks of that violence. Elsewhere Girard can speak of "the negative usefulness of religion as a social prop against anarchy and chaos" (Girard 1997, 162–63). This is salvation: violence is dealt with and human society can dwell in relative peace. Religion, on this account, is not "pie-in-the-sky," a transcendent deferral of gratification. It has real benefits to society today; it is attractive, elegant, and simple. What more could we want from religion?But Girard will not allow us to rest content with this account of religion. He is blunt when he declares that "most religions are based on a lie, which is the supposed guilt of the victim" (Girard 1993c, 32). Nietzsche wrote that "The sacrificial animal does not share the spectators' ideas about sacrifice, but one has never let it have its say,"3 and this is precisely the origin of Girard's critique of the salvation offered by religions based on scapegoating. Girard is attempting to let the sacrificial animal have its say. All too often, these... (shrink)

This article researches how a corporate code of ethics (CCE) implemented in local government X has influenced the behavior of its employees, middle managers, and managers. Metaphors from the existing and desired CCE elicited by these three groups provided information on how to improve the effectiveness of the CCE. This method proved to be very fruitful. It appeared that continuous systematic attention needed to be paid to the CCE after the CCE had been implemented, particularly by management. Initiatives from management (...) to start discussions about relevant questions of integrity appeared to be also necessary to make the topic a “normal” topic which employees were no longer afraid to discuss. In this way, the possibility could be created to develop collectively a “practical” frame of reference concerning relevant questions of integrity that would help employees to make decisions in difficult situations during their work in the future. (shrink)

Recent years have witnessed a growing interest in the measurement of health status. One of the most well-known health status instruments is the Sickness Impact Profile (SIP). This paper examines the nature, development and testing of the SIP (and its UK equivalent the FLP). The practical merits of these instruments are explained, and some cautionary remarks are offered about their limitations.

The authors focus on four major thematic areas – the reform of church, the reform of theology, the reform of perspective, and the reform of method – which together encompasses the breadth and depth of Cusanus’ own reform initiatives.

The Prologue offers an overview of the Reformation of method from Augustine of Hippo through to the Ramist movement, providing an orientation to the rest of the book. It highlights and explains an important nexus of Realism, exemplarism and illumination fundamental to Ramism. Beginning with Augustine it shows how these themes coalesced into a distinctive Christian philosophy taken up and refined by Franciscans such as Bonaventure of Bagnoregio and John Duns Scotus, as well as by Ramon Lull, the Franciscan-inspired encyclopaedist. (...) It traces the continuation of this methodological impulse into the Platonism and Christian humanism of the Renaissance, highlighting especially the topical and Realist (Scotistic) reform of logic pioneered by Lorenzo Valla and Rudolph Agricola. It concludes by showing the reception of this topical and biblical reform in Philipp Melanchthon and the movement of Reformed scholasticism, revealing Reformed Scotism and Christian philosophy as important preconditions for Ramism. (shrink)

In this paper I propose to say something about why certain key psychoanalytic concepts, particularly that of the unconscious, are special because of a studied, and therapeutically important, ambiguity or paradoxicality which affects them. Before I examine these concepts, however, the first section of this paper discusses some of Sartre's views on psychological explanation. On the one hand, this gives me a way of introducing the dichotomy of self-evident irreducibility and existential lucidity which underlies my account of the unconscious. On (...) the other hand, it is important because I take Sartre to be addressing, less successfully, the very same question that Freud dealt with by introducing his ambiguous concepts. (shrink)

Background: Mental healthcare needs person-tailored interventions. Experience Sampling Method (ESM) can provide daily life monitoring of personal experiences. This study aims to operationalize and test a measure of momentary reward-related Quality of Life (rQoL). Intuitively, quality of life improves by spending more time on rewarding experiences. ESM clinical interventions can use this information to coach patients to find a realistic, optimal balance of positive experiences (maximize reward) in daily life. rQoL combines the frequency of engaging in a relevant context (a (...) ‘behavior setting’) with concurrent (positive) affect. High rQoL occurs when the most frequent behavior settings are combined with positive affect or infrequent behavior settings co-occur with low positive affect. Methods: Resampling procedures (Monte Carlo experiments) were applied to assess the reliability of rQoL using various behavior setting definitions under different sampling circumstances, for real or virtual subjects with low-, average- and high contextual variability. Furthermore, resampling was used to assess whether rQoL is a distinct concept from positive affect. Virtual ESM beep datasets were extracted from 1058 valid ESM observations for virtual and real subjects. Results: Behavior settings defined by Who-What contextual information were most informative. Simulations of at least 100 ESM observations are needed for reliable assessment. Virtual ESM beep datasets of a real subject can be defined by Who-What-Where behavior setting combinations. Large sample sizes are necessary for reliable rQoL assessments, except for subjects with low contextual variability. rQoL is distinct from positive affect. Conclusion: rQoL is a feasible concept. Monte Carlo experiments should be used to assess the reliable implementation of an ESM statistic. Future research in ESM should asses the behavior of summary statistics under different sampling situations. This exploration is especially relevant in clinical implementation, where often only small datasets are available. (shrink)